hsa-miR-214-3p

ncRNA information

ncRNA name

hsa-miR-214-3p

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

ABCB1/XIAP

Cancer information

Cancer name

Retinoblastoma Cancer

Cancer site

Eye

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil/Carboplatin/Cisplatin/Etoposide/Vincristine

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Down

Number of patients

56

Male patients

33

Female patients

23

Age range and number

Not available

Research information

PMID

Description

Overexpression of miR-214-3p significantly sensitized retinoblastoma cells to multiple chemodrugs and promoted cell apoptosis in vitro and in vivo.

Tissue resource

retinoblastoma tissues

retinoblastoma tissues and normal retina tissues

human retinoblastoma cell lines WERI-RB1

human retinoblastoma cell lines SO-RB50

human retinoblastoma cell lines Y79

human retinal pigment epithelial cell line ARPE-19

human embryonic kidney cell line HEK-293T

Experiment

qRT-PCR,Western blot,Microarray microarray,Dual-Luciferase reporter assay


Institute

the Cangzhou Central Hospital

Cangzhou Central Hospital

American Type Culture Collection

Chinese Academy of Sciences Cell Bank

Country

China

China

United States

China

Continent

Asia

Asia

North Amercian

Asia