ncRNA name
hsa-miR-214-3p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
ABCB1/XIAP
Cancer name
Retinoblastoma Cancer
Cancer site
Eye
Treatment type
Chemotherapy
Drug
5-Fluorouracil/Carboplatin/Cisplatin/Etoposide/Vincristine
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Down
Number of patients
56
Male patients
33
Female patients
23
Age range and number
Not available
PMID
Description
Overexpression of miR-214-3p significantly sensitized retinoblastoma cells to multiple chemodrugs and promoted cell apoptosis in vitro and in vivo.
Tissue resource
retinoblastoma tissues
retinoblastoma tissues and normal retina tissues
human retinoblastoma cell lines WERI-RB1
human retinoblastoma cell lines SO-RB50
human retinoblastoma cell lines Y79
human retinal pigment epithelial cell line ARPE-19
human embryonic kidney cell line HEK-293T
Experiment
qRT-PCR,Western blot,Microarray microarray,Dual-Luciferase reporter assay
Institute
the Cangzhou Central Hospital
Cangzhou Central Hospital
American Type Culture Collection
Chinese Academy of Sciences Cell Bank
Country
China
China
United States
China
Continent
Asia
Asia
North Amercian
Asia