Circ_0080145

ncRNA information

ncRNA name

Circ_0080145

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-203 and miR-637

Cancer information

Cancer name

Chronic Myeloid Leukemia

Cancer site

qRT-PCR,Western blot

Treatment information

Treatment type

Chemotherapy

Drug

Imatinib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

36

Male patients

30

Female patients

42(<60)+24(>=60)

Age range and number

Not available

Research information

PMID

Description

The deregulation of circ_0080145 and circ_0051886 is, at least partially, responsible for the development of IM chemoresistance in CML by regulating expression of ABL1 via modulating expression of miR-203 and miR-637

Tissue resource

Experiment

66


Institute

Country

Continent