GAS5

ncRNA information

ncRNA name

GAS5

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-221-3p/DKK2

Cancer information

Cancer name

Breast Cancer

Cancer site

qRT-PCR,Western blot,Luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Adriamycin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Up

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Overexpression of GAS5 significantly enhanced the ADR sensitivity and apoptosis, and it inhibited the efflux function

Tissue resource

biopsy from breast cancer

human breast cell lines MCF-7

human breast ADR-resistant cell lines MCF-7/adriamycin

Experiment

None


Institute

First Affiliated Hospital of the University of Science and Technology of China

University of Science and Technology of China

Country

China

China

Continent

Asia

Asia