Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
GAS5
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-221-3p/DKK2
Cancer name
Breast Cancer
Cancer site
qRT-PCR,Western blot,Luciferase assay
Treatment type
Chemotherapy
Drug
Adriamycin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Up
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Overexpression of GAS5 significantly enhanced the ADR sensitivity and apoptosis, and it inhibited the efflux function
Tissue resource
biopsy from breast cancer
human breast cell lines MCF-7
human breast ADR-resistant cell lines MCF-7/adriamycin
Experiment
None
Institute
First Affiliated Hospital of the University of Science and Technology of China
University of Science and Technology of China
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.