Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CircFBXO11
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-605/FOXO3/ABCB1
Cancer name
Hepatocellular Carcinoma
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Oxaliplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
24
Male patients
16
Female patients
22(<50)+18(>=50)
Age range and number
Not available
PMID
Description
Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR-605/FOXO3/ABCB1
Tissue resource
human tumour and adjacent normal tissue specimens
human hepatocellular carcinoma cell lines HepG2
human hepatocellular carcinoma cell lines Hep3B
human hepatocellular carcinoma cell lines SMMC-7721
human hepatocellular carcinoma cell lines Huh7
normal liver cell lines Lo-2
Experiment
40
Institute
First Affiliated Hospital, Jinan University
Cell Center of Peking Union Medical College
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.