CircFBXO11

ncRNA information

ncRNA name

CircFBXO11

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-605/FOXO3/ABCB1

Cancer information

Cancer name

Hepatocellular Carcinoma

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Oxaliplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

24

Male patients

16

Female patients

22(<50)+18(>=50)

Age range and number

Not available

Research information

PMID

Description

Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR-605/FOXO3/ABCB1

Tissue resource

human tumour and adjacent normal tissue specimens

human hepatocellular carcinoma cell lines HepG2

human hepatocellular carcinoma cell lines Hep3B

human hepatocellular carcinoma cell lines SMMC-7721

human hepatocellular carcinoma cell lines Huh7

normal liver cell lines Lo-2

Experiment

40


Institute

First Affiliated Hospital, Jinan University

Cell Center of Peking Union Medical College

Country

China

China

Continent

Asia

Asia