Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
Circ_CELF1
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-491-5p/EGFR
Cancer name
Non-Small Cell Lung Cancer
Cancer site
qRT-PCR,Western blot,Luciferase assay
Treatment type
Immunotherapy
Treatment name
Impact of wild-type ncRNA on resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
20
Male patients
17
Female patients
16(<50)+21(>=50)
Age range and number
Not available
PMID
Description
circ_CELF1 acted as a miRNA sponge that increased the expression of the miR-491-5p target gene EGFR, eventually promoting the progression of NSCLC and increasing cancer resistance to immunotherapy
Tissue resource
non-small cell lung cancer tissues and adjacent normal tissues
human non-small cell lung cancer cell lines A549
human non-small cell lung cancer cell lines H1975
Experiment
37
Institute
Science Cell Laboratory
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.