Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
UCA1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
EZH2
Cancer name
Gastric Carcinoma
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
LncRNA UCA1 promotes cisplatin resistance in gastric cancer via recruiting EZH2 and activating PI3K/AKT pathway
Tissue resource
gastric cancer tissues and matched normal tissues
gastric cancer cell lines NCI-N87
gastric cancer cell lines HGC27
gastric cancer cell lines MKN45
gastric cancer cell lines MGC803
gastric cancer cell lines MKN28
gastric cancer cell lines AGS
gastric cancer cell lines SGC7901
immortalized normal gastric epithelial cell lines GES-1
Experiment
None
Institute
Ruijin Hospital
American Type Culture Collection
Shanghai Institute for Biological Sciences
Country
China
United States
China
Continent
Asia
North Amercian
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.