Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CRNDE
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
P-gp/MDR1
Cancer name
Acute Myeloid Leukemia
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Adriamycin
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Knockdown of LncRNA CRNDE suppresses proliferation and P-glycoprotein-mediated multidrug resistance in acute myelocytic leukemia through the Wnt/Ī²-catenin pathway
Tissue resource
peripheral blood samples
human acute myeloid leukemia cell lines HL60
human acute myeloid leukemia cell lines Kasumi-1
human adriamycin-resistance cell lines HL60/adriamycin
human bone marrow stromal cell lines HS-5
Experiment
None
Institute
First Affiliated Hospital of Zhengzhou University
Chinese Academy of Sciences
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.