CircMET

ncRNA information

ncRNA name

CircMET

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-30-5p/snail/DPP4

Cancer information

Cancer name

Hepatocellular Carcinoma

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Immunotherapy

Treatment name

Impact of wild-type ncRNA on resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

circMET is an onco-circRNA that induces HCC development and immune tolerance via the Snail/DPP4/CXCL10 axis

Tissue resource

Specimens obtained from the vicinity of the tumor margin were collected from patients with HCC

human HCC cell lines HCCLM3

human HCC cell lines Huh7

human HCC cell lines Hep3B

human HCC cell lines HepG2

Experiment

None


Institute

Fudan University Liver Cancer Institute

Liver Cancer Institute, Zhongshan Hospital

American Type Culture Collection

Country

China

China

United States

Continent

Asia

Asia

North Amercian