Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
DONSON
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-802/BMI1
Cancer name
Gastric Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
34
Male patients
26
Female patients
32(<50)+28(>=50)
Age range and number
Not available
PMID
Description
CircRNA DONSON contributes to cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis
Tissue resource
human gastric cancer cell lines AGS
human gastric cancer cell lines HGC-27
normal gastric mucosa from noncancerous patients and gastric cancer tissues
human gastric epithelial immortalized cell lines GES-1
Experiment
60
Institute
Third Affiliated Hospital of Soochow University
Beijing Institute for Cancer Research Collection
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.