CircPRKDC

ncRNA information

ncRNA name

CircPRKDC

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-375/FOXM1

Cancer information

Cancer name

Colorectal Cancer

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

14

Male patients

16

Female patients

11(<=60)+19(>60)

Age range and number

Not available

Research information

PMID

Description

Circ-PRKDC Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells by Regulating miR-375/FOXM1 Axis and Wnt/Ī²-Catenin Pathway

Tissue resource

tissue samples were collected from 5-FU-resistant and sensitive colorectal cancer patients

normal human fetal colonic mucosa cell lines FHC

colorectal cancer cell lines SW620

colorectal cancer cell lines SW480

Experiment

30


Institute

First Affiliated Hospital of Zhengzhou University

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian