Exosome LncRNA POU3F3

ncRNA information

ncRNA name

Exosome LncRNA POU3F3

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Not available

Cancer information

Cancer name

Esophageal Squamous Cell Carcinoma

Cancer site

qRT-PCR,Western blot

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Exosomal lncRNA POU3F3 Promotes Cisplatin Resistance in ESCC by Inducing Fibroblast Differentiation into CAFs

Tissue resource

blood samples were obtained from patients with locally advanced esophageal squamous cell carcinoma treated with CCRT

human esophageal squamous cell carcinoma cell lines KYSE450

human esophageal squamous cell carcinoma cell lines TE12

normal esophageal epithelial cell lines Het-1a

Experiment

None


Institute

Huai’an First Hospital, Nanjing Medical University

Chinese Academy of Medical Sciences

Country

China

China

Continent

Asia

Asia