Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
Exosome LncRNA POU3F3
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Esophageal Squamous Cell Carcinoma
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Exosomal lncRNA POU3F3 Promotes Cisplatin Resistance in ESCC by Inducing Fibroblast Differentiation into CAFs
Tissue resource
blood samples were obtained from patients with locally advanced esophageal squamous cell carcinoma treated with CCRT
human esophageal squamous cell carcinoma cell lines KYSE450
human esophageal squamous cell carcinoma cell lines TE12
normal esophageal epithelial cell lines Het-1a
Experiment
None
Institute
Huai’an First Hospital, Nanjing Medical University
Chinese Academy of Medical Sciences
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.