hsa_circ_0000073

ncRNA information

ncRNA name

hsa_circ_0000073

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-145-5p/miR-151-3p/NRAS

Cancer information

Cancer name

Osteosarcoma

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Methotrexate

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS

Tissue resource

osteosarcoma and paired paratumor tissues

human osteoblast cell lines hFOB 1.19

osteosarcoma cell lines MG63

osteosarcoma cell lines 143B

osteosarcoma cell lines U2OS

osteosarcoma cell lines HOS

human embryonic kidney cell lines 293T

Experiment

None


Institute

Affiliated Huai'an Hospital of Xuzhou Medical University

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian