Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
ZNF649-AS1
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
ATG5
Cancer name
Breast Cancer
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Trastuzumab
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
lncRNA ZNF649-AS1 Induces Trastuzumab Resistance by Promoting ATG5 Expression and Autophagy
Tissue resource
tissues and serum samples from HER2+ patients
human HER2+ breast cancer cell lines SKBR-3
human HER2+ breast cancer cell lines BT474
Experiment
None
Institute
The First Affiliated Hospital of Zhengzhou University and Hainan General Hospital
American Type Culture Collection
Country
China
United States
Continent
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.