Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CircTMEM181
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-488-3p
Cancer name
Hepatocellular Carcinoma
Cancer site
qRT-PCR,Western blot
Treatment type
Immunotherapy
Treatment name
Impact of wild-type ncRNA on resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
HCC-derived exosomal circTMEM181 contributes to immunosuppression and anti-PD1 resistance by elevating CD39 expression, and inhibiting the ATP-adenosine pathway by targeting CD39 on macrophages can rescue anti-PD1 therapy resistance in HCC
Tissue resource
tumor tissue samples and/or adjacent nontumorous samples were obtained from hepatocellular carcinoma patients
hepatocellular carcinoma cell lines HepG2
hepatocellular carcinoma cell lines HCCLM3
hepatocellular carcinoma cell lines MHC97H
hepatocellular carcinoma cell lines Huh-7
hepatocellular carcinoma cell lines PLC/PRF/5
hepatocellular carcinoma cell lines H22
hepatocellular carcinoma cell lines Hepa1-6
Experiment
None
Institute
Liver Cancer Institute, Zhongshan Hospital, Fudan University
Key Laboratory of Carcinogenesis and Cancer Invasion
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.