HOTAIR

ncRNA information

ncRNA name

HOTAIR

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-17-5p

Cancer information

Cancer name

Renal Cancer

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Sunitinib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

HOTAIR negatively targets miR-17-5p to activate Beclin1-mediated cell autophagy, thereby enhancing sunitinib resistance in RC cells

Tissue resource

renal cancer tissues or para-carcinoma tissues

renal cancer cell lines 786-O

renal cancer cell lines ACHN

Experiment

None


Institute

Harbin Medical University

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian