TP73-AS1

ncRNA information

ncRNA name

TP73-AS1

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

microRNA‑34a‑5p/TRIM29

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

29

Male patients

21

Female patients

27(<60)+23(>=60)

Age range and number

Not available

Research information

PMID

Description

Long non‑coding RNA TP73‑AS1 accelerates the progression and cisplatin resistance of non‑small cell lung cancer by upregulating the expression of TRIM29 via competitively targeting microRNA‑34a‑5p

Tissue resource

lung cancer specimens and paired normal tissues

non-small cell lung cancer cell lines HCC827

non-small cell lung cancer cell lines H522

non-small cell lung cancer cell lines H23

bronchial epithelial cell lines 16HBE

Experiment

50


Institute

The First People's Hospital of Tianmen

BeNa Culture Collection

Country

China

China

Continent

Asia

Asia