Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
TP73-AS1
Specific or universal ncRNAs
Specific ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
microRNAā34aā5p/TRIM29
Cancer name
Non-Small Cell Lung Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
29
Male patients
21
Female patients
27(<60)+23(>=60)
Age range and number
Not available
PMID
Description
Long nonācoding RNA TP73āAS1 accelerates the progression and cisplatin resistance of nonāsmall cell lung cancer by upregulating the expression of TRIM29 via competitively targeting microRNAā34aā5p
Tissue resource
lung cancer specimens and paired normal tissues
non-small cell lung cancer cell lines HCC827
non-small cell lung cancer cell lines H522
non-small cell lung cancer cell lines H23
bronchial epithelial cell lines 16HBE
Experiment
50
Institute
The First People's Hospital of Tianmen
BeNa Culture Collection
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.