Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-107
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
HMGA2/mTOR/P-gp
Cancer name
Gastric Cancer
Cancer site
qRT-PCR,Western blot,Luciferase assay
Treatment type
Chemotherapy
Drug
Cisplatin/6-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
These findings demonstrated that exosome-transmitted miR-107 significantly enhanced the sensitivity of resistant gastric cancer cells to chemotherapeutic agents by mediating the HMGA2/mTOR/P-gp axis
Tissue resource
human gastric cancer 5-FU sensitive/resistant cell lines SGC-7901
human gastric cancer cisplatin sensitive/resistant cell lines SGC-7901
Experiment
None
Institute
Huiying BioTech
Country
China
Continent
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.