ASAP1

ncRNA information

ncRNA name

ASAP1

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

EIF4A3

Downstream target

NRAS/MEK1/ERK1-2

Cancer information

Cancer name

Glioblastoma

Cancer site

qRT-PCR,Western blot,Luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Temozolomide

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling

Tissue resource

primary glioblastoma specimens and recurrent glioblastoma specimens

drug-related glioblastoma cell lines N3S

drug-related glioblastoma cell lines N3T3rd

drug-related glioblastoma cell lines U251

drug-related glioblastoma cell lines U251T3rd

Experiment

None


Institute

the First Affiliated Hospital of Nanjing Medical University

Country

China

Continent

Asia