HOTAIR

ncRNA information

ncRNA name

HOTAIR

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-149-5p/DCLK1

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

qRT-PCR,Western blot,Luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

38

Male patients

32

Female patients

31(<60)+39(>=60)

Age range and number

Not available

Research information

PMID

Description

Knockdown of Long Non-Coding RNA HOTAIR Suppresses Cisplatin Resistance

Tissue resource

non-small cell lung cancer tumor tissues

human non-small cell lung cancer cell lines A549

human non-small cell lung cancer cell lines H1299

Experiment

70


Institute

the Affiliated Tumor Hospital of Xinjiang Medical University

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian