Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
LUCAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-514a-3p/ULK1
Cancer name
Non-Small Cell Lung Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
32
Male patients
28
Female patients
32(<=65)+28(>65)
Age range and number
Not available
PMID
Description
Long non-coding RNA LUCAT1 contributes to cisplatin resistance by regulating the miR-514a-3p/ULK1 axis in human non-small cell lung cancer
Tissue resource
cisplatin-resistant non-small cell lung cancer tissues and cisplatin-sensitive non-small cell lung cancer tissues and tumor-adjacent normal tissues
normal human lung fibroblasts cell lines IMR90
non-small cell lung cancer cell lines A549
Experiment
60
Institute
First Hospital of China Medical University
American Type Culture Collection
Country
China
United States
Continent
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.