CTRR-ncRNA

ncRNA information

ncRNA name

MSC-AS1

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-373-3p/CPEB4

Cancer information

Cancer name

Glioma

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Temozolomide

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

32

Male patients

18

Female patients

20(<60)+30(>=60)

Age range and number

Not available

Research information

PMID

33106913

Description

MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway

Tissue resource

glioma tissues and peritumoral brain edema tissues

human glioma cell lines LN229

human glioma cell lines SHG-44

Renal epithelial cell lines 293T

Experiment

50

Institute

Chinese PLA General Hospita

Procell

Country

China

Continent

Asia