Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
Circ_0007841
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-129-5p/JAG1
Cancer name
Multiple Myeloma
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Bortezomib
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Depletion of circ_0007841 inhibits multiple myeloma development and BTZ resistance via miR-129-5p/JAG1 axis
Tissue resource
bone marrow from multiple myeloma patients and healthy individuals
human normal plasma cell lines nPCs
multiple myeloma cell lines OPM2
multiple myeloma cell lines JJN3
Experiment
None
Institute
The Fifth Affiliated Hospital of Zhengzhou University
Miltenyi Biotec
Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH
Country
China
Germany
Germany
Continent
Asia
European
European
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.