XIST

ncRNA information

ncRNA name

XIST

Specific or universal ncRNAs

Universal ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

microRNA-29a/MYC

Cancer information

Cancer name

Acute Myeloid Leukemia

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Adriamycin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Silencing long non-coding RNA XIST suppresses drug resistance in acute myeloid leukemia through down-regulation of MYC by elevating microRNA-29a expression

Tissue resource

bone marrow samples from acute myeloid leukemia

acute myeloid leukemia cell lines KG-1

Experiment

None


Institute

The First Affiliated Hospital of Zhengzhou University

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian