CircFN1

ncRNA information

ncRNA name

CircFN1

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-1205/E2F1

Cancer information

Cancer name

Hepatocellular Carcinoma

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Sorafenib

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

In summary, our study demonstrated that circFN1 contributes to sorafenib resistance by regulating the miR-1205/E2F1 signaling pathway

Tissue resource

paired hepatocellular carcinoma tissues

hepatocellular carcinoma cell lines HepG2

hepatocellular carcinoma cell lines Huh-7

normal human liver cell lines LO2

Experiment

None


Institute

Shanghai Eastern Hepatobiliary Surgery Hospital

the Chinese Academy of Sciences Cell Bank Type Culture Collection

Country

China

Continent

Asia