Circ_0003998

ncRNA information

ncRNA name

Circ_0003998

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-218-5p/EIF5A2

Cancer information

Cancer name

Hepatocellular Carcinoma

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Doxorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Circ_0003998 enhances doxorubicin resistance in hepatocellular carcinoma by regulating miR-218-5p/EIF5A2 pathway

Tissue resource

primary hepatocellular carcinoma tissues and adjacent normal tissues

hepatocellular carcinoma cell lines Hep3B

hepatocellular carcinoma cell lines Huh7

hepatocellular carcinoma cell lines HCCLM3

hepatocyte cell lines THLE-2

Experiment

None


Institute

Shanxi Medical University

Shanghai Academy of Life Science

Country

China

China

Continent

Asia

Asia