Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
BLACAT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-519d-3p/CREB1
Cancer name
Colorectal Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Oxaliplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
LncRNA BLACAT1/miR-519d-3p/CREB1 Axis Mediates Proliferation, Apoptosis, Migration, Invasion, and Drug-Resistance in Colorectal Cancer Progression
Tissue resource
paired colorectal cancer tumors and adjacent normal mucosa tissues
normal human intestinal epithelial cell lines HIEC-6
colorectal cancer cell lines HCT116
colorectal cancer cell lines HT29
colorectal cancer cell lines LOVO
colorectal cancer cell lines SW620
colorectal cancer oxaliplatin-resistant cell lines HT29/OXA
colorectal cancer oxaliplatin-resistant cell lines HCT116/OXA
Experiment
None
Institute
Department of General Surgery, Taizhou Hospital of Zhejiang Province
Cell Center of Shanghai Institutes for Biological Sciences
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.