Circ_ZFR

ncRNA information

ncRNA name

Circ_ZFR

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-195-5p

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Circ_ZFR contributes to the paclitaxel resistance and progression of non-small cell lung cancer by upregulating KPNA4 through sponging miR-195-5p

Tissue resource

non-small cell lung cancer tissue specimens and adjacent normal tissue specimens

human bronchial epithelial cell lines HBE

non-small cell lung cancer cell lines A549

non-small cell lung cancer cell lines H460

Experiment

None


Institute

Renmin Hospital, Hubei University of Medicine

Procell

Country

China

China

Continent

Asia

Asia