CTRR-ncRNA

ncRNA information

ncRNA name

LINC00665

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-424-5p/BCL9L

Cancer information

Cancer name

Cholangiocarcinoma

Cancer site

qRT-PCR,Western blot,Luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Gemcitabine

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

49

Male patients

51

Female patients

Not available

Age range and number

Not available

Research information

PMID

33436545

Description

Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis

Tissue resource

cholangiocarcinoma samples and paired adjacent normal bile duct tissues

cholangiocarcinoma cell lines HuCCT1

cholangiocarcinoma cell lines HuH28

cholangiocarcinoma cell lines SNU-1196

cholangiocarcinoma cell lines SNU-1079

cholangiocarcinoma cell lines SNU-308

cholangiocarcinoma cell lines SNU-245

cholangiocarcinoma cell lines SNU-478

cholangiocarcinoma cell lines SNU-869

Experiment

100

Institute

Henan Provincial People's Hospital

Japan Health Science Research Resources Bank

Korea Cell Line Bank

Country

China

Japan

Korea

Continent

Asia