Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
APCDD1L-AS1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-1322/miR-1972/miR-324-3p-SIRT5
Cancer name
Lung Adenocarcinoma
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Icotinib
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
LncRNA APCDD1L-AS1 induces icotinib resistance by inhibition of EGFR autophagic degradation via the miR-1322/miR-1972/miR-324-3p-SIRT5 axis in lung adenocarcinoma
Tissue resource
human lung adenocarcinoma cell lines PC9
human lung adenocarcinoma cell lines HCC827
low-dose icotinib-resistant lung adenocarcinoma cell lines HCC827/IcoRL
high-dose icotinib-resistant lung adenocarcinoma cell lines HCC827/IcoRH
Experiment
None
Institute
American Type Culture Collection
Betta Pharmaceuticals Co Ltd
Country
United States
China
Continent
North Amercian
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.