Exosome HOTTIP

ncRNA information

ncRNA name

Exosome HOTTIP

Specific or universal ncRNAs

Specific ncRNAs

Class

Long noncoding RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

MiR-214/KPNA3

Cancer information

Cancer name

Colorectal Cancer

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Mitomycin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Exosomal Long Non-coding RNA HOTTIP Increases Resistance of Colorectal Cancer Cells to Mitomycin via Impairing MiR-214-Mediated Degradation of KPNA3

Tissue resource

blood samples from patients with advanced colorectal

colorectal cancer cell lines HCT116

colorectal cancer cell lines SW620

human normal intestinal epithelial cell lines FHC

Experiment

None


Institute

the Affiliated Tumor Hospital of Zhengzhou University

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian