Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa_circ_0002874
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-1273f/MDM2/p53
Cancer name
Non-Small Cell Lung Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
10
Male patients
10
Female patients
8(<65)+12(>=65)
Age range and number
Not available
PMID
Description
Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway
Tissue resource
non-small cell lung cancer tissues and paired non-cancerous matched tissues
human non-small cell lung cancer cell lines A549
human non-small cell lung cancer paclitaxel-resistant cell lines A549/Taxol
Experiment
20
Institute
he Second Affiliated Hospital of Suzhou University
the Cell Bank of Type Culture Collection of the Chinese Academy of Sciences
Yaji Biotechnology Company
Country
China
China
China
Continent
Asia
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.