hsa_circ_0002874

ncRNA information

ncRNA name

hsa_circ_0002874

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-1273f/MDM2/p53

Cancer information

Cancer name

Non-Small Cell Lung Cancer

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

10

Male patients

10

Female patients

8(<65)+12(>=65)

Age range and number

Not available

Research information

PMID

Description

Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway

Tissue resource

non-small cell lung cancer tissues and paired non-cancerous matched tissues

human non-small cell lung cancer cell lines A549

human non-small cell lung cancer paclitaxel-resistant cell lines A549/Taxol

Experiment

20


Institute

he Second Affiliated Hospital of Suzhou University

the Cell Bank of Type Culture Collection of the Chinese Academy of Sciences

Yaji Biotechnology Company

Country

China

China

China

Continent

Asia

Asia

Asia