Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CircWAC
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-142/WWP1
Cancer name
Triple-Negative Breast Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway
Tissue resource
paired triple-negative breast cancer tumor and paracancer tissue samples
triple-negative breast cancer cell lines MDA-MB-231
triple-negative breast cancer cell lines MDA-MB-468
triple-negative breast cancer cell lines HCC-1937
triple-negative breast cancer cell lines MDA-MB-361
triple-negative breast cancer cell lines MCF-7
triple-negative breast cancer cell lines MCF-10A
Experiment
None
Institute
the First Affiliated Hospital of Soochow University
American Type Culture Collection
Country
China
United States
Continent
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.