CircWAC

ncRNA information

ncRNA name

CircWAC

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-142/WWP1

Cancer information

Cancer name

Triple-Negative Breast Cancer

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway

Tissue resource

paired triple-negative breast cancer tumor and paracancer tissue samples

triple-negative breast cancer cell lines MDA-MB-231

triple-negative breast cancer cell lines MDA-MB-468

triple-negative breast cancer cell lines HCC-1937

triple-negative breast cancer cell lines MDA-MB-361

triple-negative breast cancer cell lines MCF-7

triple-negative breast cancer cell lines MCF-10A

Experiment

None


Institute

the First Affiliated Hospital of Soochow University

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian