Circ_0000338

ncRNA information

ncRNA name

Circ_0000338

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

Yes

Biomarker application

Diagnosis/Treatment

Upstream regulatory factors

Not available

Downstream target

miR-217/miR-485-3p

Cancer information

Cancer name

Colorectal Cancer

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

17-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

19

Male patients

17

Female patients

24(<60)+12(>=60)

Age range and number

Not available

Research information

PMID

Description

The delivery of circ_0000338 via exosomes enhanced 5-FU resistance in CRC through negative regulation of miR-217 and miR-485-3p, indicating a promising diagnostic and therapeutic marker for 5-FU-based chemotherapy in CRC patients

Tissue resource

tumor tissues were obtained from surgical specimens or biopsy specimens

human colorectal cancer cell lines SW480

human colorectal cancer cell lines HCT116

Experiment

36


Institute

the Second Affiliated Hospital of Soochow University

the Chinese Academy of Sciences

Country

China

China

Continent

Asia

Asia