Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
Circ_0000338
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
Yes
Biomarker application
Diagnosis/Treatment
Upstream regulatory factors
Not available
Downstream target
miR-217/miR-485-3p
Cancer name
Colorectal Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
17-Fluorouracil
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Up
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
19
Male patients
17
Female patients
24(<60)+12(>=60)
Age range and number
Not available
PMID
Description
The delivery of circ_0000338 via exosomes enhanced 5-FU resistance in CRC through negative regulation of miR-217 and miR-485-3p, indicating a promising diagnostic and therapeutic marker for 5-FU-based chemotherapy in CRC patients
Tissue resource
tumor tissues were obtained from surgical specimens or biopsy specimens
human colorectal cancer cell lines SW480
human colorectal cancer cell lines HCT116
Experiment
36
Institute
the Second Affiliated Hospital of Soochow University
the Chinese Academy of Sciences
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.