Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CircHUWE1
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-34a-5p
Cancer name
Non-Small Cell Lung Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Cisplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
circHUWE1 functioned as a promoter in DDP-resistant NSCLC by interaction with miR-34a-5p-TNFAIP8 networks
Tissue resource
non-small cell lung cancer tissues and adjacent nontumorous tissues
non-small cell lung cancer cell lines 549
non-small cell lung cancer cell lines H1299
non-small cell lung cancer cisplatin-resistant cell lines A549/DDP
non-small cell lung cancer cisplatin-resistant cell lines H1299/DDP
lung epithelial cell lines BEAS-2B
Experiment
None
Institute
Shanxi Provincial Cancer Hospital
Nanjing Key Gen Biotech
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.