Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CircDLG1
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-141-3p/CXCL12
Cancer name
Gastric Cancer
Cancer site
qRT-PCR,Western blot
Treatment type
Immunotherapy
Treatment name
Impact of wild-type ncRNA on resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
circDLG1 interacted with miR-141-3p and acted as a miRNA sponge to increase the expression of CXCL12, which promoted gastric cancer progression and resistance to anti-PD-1-based therapy
Tissue resource
primary tissues and adjacent normal tissues and distant metastatic tissues
human gastric cancer cell lines HGC27
human gastric cancer cell lines BGC823
human gastric cancer cell lines MKN45
human gastric cancer cell lines MKN28
human gastric cancer cell lines SGC7901
human gastric cancer cell lines AGS
normal gastric epithelial cell lines GES-1
murine gastric cancer cell lines MFC
human embryonic kidney cell lines 293T
Experiment
None
Institute
Sun Yat-sen University Cancer Center
Shanghai Institute of Cell Biology
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.