hsa-miR-454-3p

ncRNA information

ncRNA name

hsa-miR-454-3p

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PTEN

Cancer information

Cancer name

Colorectal Cancer

Cancer site

qRT-PCR,Western blot,Luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Oxaliplatin

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

11

Male patients

12

Female patients

10(<60)+13(>=60)

Age range and number

Not available

Research information

PMID

Description

MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer

Tissue resource

human colorectal cancer samples

human colorectal cancer cell lines HCT-116

Experiment

23


Institute

Zhangjiagang First People's Hospital

the Cell Bank of the Chinese Academy of Sciences

Country

China

China

Continent

Asia

Asia