Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-5000-3p
Specific or universal ncRNAs
Specific ncRNAs
Class
MicroRNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
USP49
Cancer name
Colorectal Cancer
Cancer site
qRT-PCR,Western blot,Luciferase assay
Treatment type
Chemotherapy
Drug
Oxaliplatin
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
215
Male patients
188
Female patients
199(<69)+204(>=69)
Age range and number
Not available
PMID
Description
miR-5000-3p confers oxaliplatin resistance by targeting ubiquitin-specific peptidase 49 in colorectal cancer
Tissue resource
primary colorectal cancer tissues
colorectal cancer cell lines HCT116
colorectal cancer cell lines HCT8
colorectal cancer cell lines HT29
colorectal cancer cell lines LoVo
colorectal cancer cell lines DLD-1
colorectal cancer cell lines SW620
colorectal cancer cell lines SW480
colorectal cancer cell lines Caco-2
normal human intestinal epithelial cell line HIEC-6
Experiment
403
Institute
Sun Yat-sen Memorial Hospital
Shanghai Cell Bank of Chinese Academy of Sciences
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.