hsa-miR-1246

ncRNA information

ncRNA name

hsa-miR-1246

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

AXIN2/GSK-3Ī²

Cancer information

Cancer name

Leukemia

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

None

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

these mean that targeting miR-1246-AXIN2/GSK-3Ī²-Wnt/Ī²-catenin axis may be beneficial to overcome the chemo-resistance in relapse and refractory leukemia patients

Tissue resource

blood samples from leukemia patients

leukemia cell lines K562

leukemia cell lines HL-60

leukemia drug-resistant cell lines K562/doxorubicin

Experiment

None


Institute

the First Hospital of Lanzhou University

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian