Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-1246
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
AXIN2/GSK-3Ī²
Cancer name
Leukemia
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
None
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
these mean that targeting miR-1246-AXIN2/GSK-3Ī²-Wnt/Ī²-catenin axis may be beneficial to overcome the chemo-resistance in relapse and refractory leukemia patients
Tissue resource
blood samples from leukemia patients
leukemia cell lines K562
leukemia cell lines HL-60
leukemia drug-resistant cell lines K562/doxorubicin
Experiment
None
Institute
the First Hospital of Lanzhou University
American Type Culture Collection
Country
China
United States
Continent
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.