Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
PVT1
Specific or universal ncRNAs
Universal ncRNAs
Class
Long noncoding RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-365/ELF4/SOX2
Cancer name
Glioma
Cancer site
qRT-PCR,Western blot
Treatment type
Chemotherapy
Drug
Temozolomide
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
18
Male patients
12
Female patients
17(<50)+13(>50)
Age range and number
Not available
PMID
Description
Long Noncoding RNA PVT1 Promotes Stemness and Temozolomide Resistance through miR-365/ELF4/SOX2 Axis in Glioma
Tissue resource
glioma tissue specimens and normal brain tissue specimens
human astrocyte normal cell lines HEB
human glioma cell lines T98G
human glioma cell lines A172
human glioma cell lines U87
human glioma cell lines U251
human glioma cell lines U373
Experiment
30
Institute
Zhongnan Hospital of Wuhan University
American Type Culture Collection
Country
China
United States
Continent
Asia
North Amercian
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.