Exosome miR-25-3p

ncRNA information

ncRNA name

Exosome miR-25-3p

Specific or universal ncRNAs

Specific ncRNAs

Class

MicroRNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

FBXW7

Cancer information

Cancer name

Glioblastoma

Cancer site

qRT-PCR,Western blot,Luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Temozolomide

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

39

Male patients

37

Female patients

35(<=60)+41(>60)

Age range and number

Not available

Research information

PMID

Description

Exosomal transfer of miR-25-3p promotes the proliferation and temozolomide resistance of glioblastoma cells by targeting FBXW7

Tissue resource

Serum samples from patients with glioblastoma treated with temozolomide and untreated patients with glioblastoma and healthy donors

human embryonic kidney cell lines 293T

glioblastoma cell lines U87

glioblastoma cell lines A172

Experiment

76


Institute

Henan Provincial People's Hospital

American Type Culture Collection

Country

China

United States

Continent

Asia

North Amercian