Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
CircHIPK3
Specific or universal ncRNAs
Specific ncRNAs
Class
Circular RNA
Biomarker
None
Biomarker application
Upstream regulatory factors
Not available
Downstream target
miR-1286/HK2
Cancer name
Breast Cancer
Cancer site
qRT-PCR,Western blot,Dual-luciferase assay
Treatment type
Chemotherapy
Drug
Paclitaxel
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Down
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Up
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
the silencing of circHIPK3 sensitized PTX-resistant BC cells to PTX therapy at least in part via the regulation of the miR-1286/HK2 axis
Tissue resource
tissue samples from primary breast cancer patients and recurrent patients after treatment based on paclitaxelchemotherapy and adjacent normal breast tissue samples from these patients
human breast cell lines MDA-MB-231
human breast cell lines MCF-7
human breast paclitaxel-resistant cell lines MDA-MB-231/paclitaxel
human breast paclitaxel-resistant cell lines MCF-7/paclitaxel
Experiment
None
Institute
People's Hospital of Ganzhou City
Procell
Country
China
China
Continent
Asia
Asia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.