CircHIPK3

ncRNA information

ncRNA name

CircHIPK3

Specific or universal ncRNAs

Specific ncRNAs

Class

Circular RNA

Biomarker

None

Biomarker application

Upstream regulatory factors

Not available

Downstream target

miR-1286/HK2

Cancer information

Cancer name

Breast Cancer

Cancer site

qRT-PCR,Western blot,Dual-luciferase assay

Treatment information

Treatment type

Chemotherapy

Drug

Paclitaxel

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Up

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

the silencing of circHIPK3 sensitized PTX-resistant BC cells to PTX therapy at least in part via the regulation of the miR-1286/HK2 axis

Tissue resource

tissue samples from primary breast cancer patients and recurrent patients after treatment based on paclitaxelchemotherapy and adjacent normal breast tissue samples from these patients

human breast cell lines MDA-MB-231

human breast cell lines MCF-7

human breast paclitaxel-resistant cell lines MDA-MB-231/paclitaxel

human breast paclitaxel-resistant cell lines MCF-7/paclitaxel

Experiment

None


Institute

People's Hospital of Ganzhou City

Procell

Country

China

China

Continent

Asia

Asia