Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-221
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
p27Kip1
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1.
Tissue resource
human breast cancer tamoxifen-sensitive cell lines MCF-7
human breast cancer 4-hydroxytamoxifen-resistant cells lines OHT
human breast cancer tamoxifen-sensitive cell lines MCF-7
human breast cancer 4-hydroxytamoxifen-resistant cells lines OHT
Experiment
qRT-PCR
Institute
Indiana University
Country
USA
Continent
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.