Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-221
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
No
Biomarker application
Upstream regulatory factors
Not available
Downstream target
Not available
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Fulvestrant
Impact of wild-type ncRNA on chemotherapy resistance
Up
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways.
Tissue resource
human breast cancer cell lines BT474
human breast cancer cell lines MCF7
human breast cancer fulvestrant-resistant cell lines MCF7-F
human breast cancer cell lines BT474
human breast cancer cell lines MCF7
human breast cancer fulvestrant-resistant cell lines MCF7-F
Experiment
qRT-PCR,Western blot
Institute
American Type Culture Collection
Country
USA
Continent
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.