hsa-miR-34a

ncRNA information

ncRNA name

hsa-miR-34a

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Sirt1

Cancer information

Cancer name

Colon Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Increased intracellular miRNA-34a level attenuated the resistance to 5-FU through down-regulation of Sirt1.

Tissue resource

human colon cancer cell lines DLD-1

human colon cancer 5-FU-resistant cell lines DLD-1/5FU

Experiment

qRT-PCR,Western blot


Institute

Country

Continent