CTRR-ncRNA

ncRNA information

ncRNA name

hsa-miR-21

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

hMSH2

Cancer information

Cancer name

Colorectal Cancer

Cancer site

Colon, Rectum, and Anus

Treatment information

Treatment type

Chemotherapy

Drug

5-Fluorouracil

Impact of wild-type ncRNA on chemotherapy resistance

Up

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

21078976

Description

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog2.

Tissue resource

human colorectal cancer cell lines Colo-320 DM

human colorectal cancer cell lines SW620

human colorectal cancer cell lines HCT-116

human colorectal cancer cell lines SW480

human colorectal cancer cell lines RKO

Experiment

qRT-PCR

Institute

Country

Continent