hsa-miR-21

ncRNA information

ncRNA name

hsa-miR-21

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

PTEN

Cancer information

Cancer name

Leukemia

Cancer site

Leukemia

Treatment information

Treatment type

Chemotherapy

Drug

Daunorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Down

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Knockdown of miR-21 partially sensitizes the K562/DNR cells to DNR.

Tissue resource

leukaemia cell lines K562

leukaemia daunorubicin-resistant cell lines K562/DNR

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

Shanghai Ruijin Hospital

Country

China

Continent

Asia