hsa-miR-125b

ncRNA information

ncRNA name

hsa-miR-125b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

Not available

Cancer information

Cancer name

Pediatric Acute Promyelocytic Leukemia

Cancer site

Leukemia

Treatment information

Treatment type

Chemotherapy

Drug

Doxorubicin

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Up

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia.

Tissue resource

pediatric acute myeloid leukemia samples

human leukemia cell lines NB4

human leukemia cell lines HL60

human leukemia cell lines K562

human leukemia drug resistant cell lines NB4-R1

Experiment

qRT-PCR,Western blot,Luciferase reporter assay


Institute

the First and Second Affiliated Hospital of Sun Yat-sen University and Beijing Children's Hospital

Country

China

Continent

Asia