hsa-miR-200b

ncRNA information

ncRNA name

hsa-miR-200b

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

BCL2/XIAP

Cancer information

Cancer name

Gastric Cancer

Cancer site

Stomach

Treatment information

Treatment type

Chemotherapy

Drug

Cisplatin/Vincristine

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Overexpression of miR-200bc/429 cluster sensitized SGC7901/VCR and A549/CDDP cells to anti-cancer drugs, respectively.

Tissue resource

human gastric adenocarcinoma cell lines SGC7901

human gastric adenocarcinoma multidrug-resistant cell lines SGC7901/VCR

human lung cancer cell lines A549

human lung cancer multidrug-resistant cell lines A549/CDDP

human gastric adenocarcinoma cell lines SGC7901

human gastric adenocarcinoma multidrug-resistant cell lines SGC7901/VCR

human lung cancer cell lines A549

human lung cancer multidrug-resistant cell lines A549/CDDP

human gastric adenocarcinoma cell lines SGC7901

human gastric adenocarcinoma multidrug-resistant cell lines SGC7901/VCR

human lung cancer cell lines A549

human lung cancer multidrug-resistant cell lines A549/CDDP

Experiment

qRT-PCR,Western blot,Dual-luciferase reporter assay


Institute

Academy of Military Medical Science

the Xijing Hospital of Fourth Military Medical University

Biosis Biotechnology Company

Academy of Military Medical Science

Xijing Hospital, Fourth Military Medical University

Biosis Biotechnology Company

Academy of Military Medical Science

Xijing Hospital, Fourth Military Medical University

Biosis Biotechnology Company

Country

China

China

China

Continent

Asia

Asia

Asia