hsa-miR-100

ncRNA information

ncRNA name

hsa-miR-100

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

No

Biomarker application

Upstream regulatory factors

Not available

Downstream target

Plk1

Cancer information

Cancer name

Lung Adenocarcinoma

Cancer site

Lung

Treatment information

Treatment type

Chemotherapy

Drug

Docetaxel

Impact of wild-type ncRNA on chemotherapy resistance

Down

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

MiR-100 resensitizes docetaxel-resistant human lung adenocarcinoma cells (SPC-A1) to docetaxel by targeting Plk1.

Tissue resource

lung adenocarcinoma tissues

human lung adenocarcinoma cell lines SPC-A1

human lung adenocarcinoma cell lines A549

human lung adenocarcinoma cell lines NCI-H1299

Experiment

qRT-PCR,Western blot,Dual-luciferase reporter assay


Institute

Jinling Hospital

American Type Culture Collection

Country

China

USA

Continent

Asia

Amercia