hsa-miR-375

ncRNA information

ncRNA name

hsa-miR-375

Specific or universal ncRNAs

Universal ncRNAs

Class

MicroRNA

Biomarker

Yes

Biomarker application

Treatment

Upstream regulatory factors

Not available

Downstream target

MTDH

Cancer information

Cancer name

Breast Cancer

Cancer site

Breast

Treatment information

Treatment type

Chemotherapy

Drug

Tamoxifen

Impact of wild-type ncRNA on chemotherapy resistance

Impact of knockdown of ncRNA on chemotherapy resistance

Impact of overexpression of ncRNA on chemotherapy resistance

Down

Clinical Information

ncRNA differential expression in
cancer patients vs. healthy people

Not available

Number of patients

Not available

Male patients

Not available

Female patients

Not available

Age range and number

Not available

Research information

PMID

Description

Re-expression of miR-375 was sufficient to sensitize TamR cells to tamoxifen and partly reversed EMT.

Tissue resource

human ovarian cancer cell lines Ovcar-5

human breast cancer cell lines MCF-7

human breast cancer cell lines MDA-MB-231

lung cancer cell lines H1703

lung cancer cell lines H1299

human embryonic kidney cell lines HEK-293T

Experiment

qRT-PCR,Western blot


Institute

American Type Culture Collection

Invitrogen

Country

USA

Continent

Amercia