Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.
ncRNA name
hsa-miR-375
Specific or universal ncRNAs
Universal ncRNAs
Class
MicroRNA
Biomarker
Yes
Biomarker application
Treatment
Upstream regulatory factors
Not available
Downstream target
MTDH
Cancer name
Breast Cancer
Cancer site
Breast
Treatment type
Chemotherapy
Drug
Tamoxifen
Impact of wild-type ncRNA on chemotherapy resistance
Impact of knockdown of ncRNA on chemotherapy resistance
Impact of overexpression of ncRNA on chemotherapy resistance
Down
ncRNA differential expression in
cancer
patients vs. healthy people
Not available
Number of patients
Not available
Male patients
Not available
Female patients
Not available
Age range and number
Not available
PMID
Description
Re-expression of miR-375 was sufficient to sensitize TamR cells to tamoxifen and partly reversed EMT.
Tissue resource
human ovarian cancer cell lines Ovcar-5
human breast cancer cell lines MCF-7
human breast cancer cell lines MDA-MB-231
lung cancer cell lines H1703
lung cancer cell lines H1299
human embryonic kidney cell lines HEK-293T
Experiment
qRT-PCR,Western blot
Institute
American Type Culture Collection
Invitrogen
Country
USA
Continent
Amercia
Institutes for Systems Genetics, West China Hospital
Copyright @ 2022 ISG. All Rights Reserved.